Investigations of Ta and Nb doped KTiOPO4 derivatives

The non-linear optical material KTiOPO4 (KTP) has been established as an industry standard material for frequency-doubling of Nd:YAG 1μm radiation into the green visible range. Technological requirements for extended frequency-doubling into the visible blue have prompted the pursuit of doped KTP isomorphs which possess the already desirable characteristics of KTP itself, with modified non-linear optical responses to produce novel, useful materials. This thesis is an investigation of the crystal quality of some of these KTP isomorphs and the structural features of one such material. High-resolution x-ray diffraction techniques are used to examine the structural quality of Nb, Ta and Ta/Ga doped KTP. It is demonstrated that differing perfection is found for these materials compared to pure KTP, and each possesses a degree of mosaicity. Single-crystal diffraction is used to carry out a detailed structural refinement for 4% Ta-doped KTP, and demonstrates the similarity of this structure to previously refined structures for Nb-doped KTP. A potential new site for Ta incorporation into the unit cell is suggested. A simulation of the material’s refractive indices, based on polarisability volume calculations, is carried out. The significance of the simulation is discussed in the context of improved optical performance of these crystals. White-beam synchrotron radiation topographic studies are carried out for the Ta and Ta/Ga-doped KTP materials, and the presence of significant defect structures and associated domains is reported. The implications for non-linear optical quality are discussed

Turbulent Scalar Mixing in a Skewed Jet in Crossflow: Experiments and Modeling

Turbulent mixing of an inclined, skewed jet injected into a crossflow is investigated using MRI-based experiments and a high-fidelity LES of the same configuration. The MRI technique provides three-dimensional fields of mean velocity and mean jet concentration. The 30° skew of the jet relative to the crossflow produces a single dominant vortex which introduces spanwise asymmetries to the velocity and concentration fields. The turbulent scalar transport of the skewed jet is investigated in further detail using the LES, which is validated against the experimental measurements. Mixing is found to be highly anisotropic throughout the jet region. Isotropic turbulent diffusivity and viscosity are used to calculate an optimal value of the turbulent Schmidt number, which varies widely over the jet region and lies mostly outside of the typically accepted range 0.7 ≤ Sct ≤ 0.9. Finally, three common scalar flux models of increasing complexity are evaluated based on their ability to capture the anisotropy and predict the scalar concentration field of the present configuration. The higher order models are shown to better represent the turbulent scalar flux vector, leading to more accurate calculations of the concentration field. While more complex models are better able to capture the turbulent mixing, optimization of model constants is shown to significantly affect the results

Recent origin of low trabecular bone density in modern humans

Humans are unique, compared with our closest living relatives (chimpanzees) and early fossil hominins, in having an enlarged body size and lower limb joint surfaces in combination with a relatively gracile skeleton (i.e., lower bone mass for our body size). Some analyses have observed that in at least a few anatomical regions modern humans today appear to have relatively low trabecular density, but little is known about how that density varies throughout the human skeleton and across species or how and when the present trabecular patterns emerged over the course of human evolution. Here, we test the hypotheses that (i) recent modern humans have low trabecular density throughout the upper and lower limbs compared with other primate taxa and (ii) the reduction in trabecular density first occurred in early Homo erectus, consistent with the shift toward a modern human locomotor anatomy, or more recently in concert with diaphyseal gracilization in Holocene humans. We used peripheral quantitative CT and microtomography to measure trabecular bone of limb epiphyses (long bone articular ends) in modern humans and chimpanzees and in fossil hominins attributed to Australopithecus africanus, Paranthropus robustus/early Homo from Swartkrans, Homo neanderthalensis, and early Homo sapiens. Results show that only recent modern humans have low trabecular density throughout the limb joints. Extinct hominins, including pre-Holocene Homo sapiens, retain the high levels seen in nonhuman primates. Thus, the low trabecular density of the recent modern human skeleton evolved late in our evolutionary history, potentially resulting from increased sedentism and reliance on technological and cultural innovations

Differential rates of perinatal maturation of human primary and nonprimary auditory cortex

Abstract Primary and nonprimary cerebral cortex mature along different timescales; however, the differences between the rates of maturation of primary and nonprimary cortex are unclear. Cortical maturation can be measured through changes in tissue microstructure detectable by diffusion magnetic resonance imaging (MRI). In this study, diffusion tensor imaging (DTI) was used to characterize the maturation of Heschl’s gyrus (HG), which contains both primary auditory cortex (pAC) and nonprimary auditory cortex (nAC), in 90 preterm infants between 26 and 42 weeks postmenstrual age (PMA). The preterm infants were in different acoustical environments during their hospitalization: 46 in open ward beds and 44 in single rooms. A control group consisted of 15 term-born infants. Diffusion parameters revealed that (1) changes in cortical microstructure that accompany cortical maturation had largely already occurred in pAC by 28 weeks PMA, and (2) rapid changes were taking place in nAC between 26 and 42 weeks PMA. At term equivalent PMA, diffusion parameters for auditory cortex were different between preterm infants and term control infants, reflecting either delayed maturation or injury. No effect of room type was observed. For the preterm group, disturbed maturation of nonprimary (but not primary) auditory cortex was associated with poorer language performance at age two years

Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model.

Laser-induced experimental glaucoma (ExGl) in non-human primates (NHPs) is a common animal model for ocular drug development. While many features of human hypertensive glaucoma are replicated in this model, structural and functional changes in the unlasered portions of trabecular meshwork (TM) of laser-treated primate eyes are understudied. We studied NHPs with ExGl of several years duration. As expected, ExGl eyes exhibited selective reductions of the retinal nerve fiber layer that correlate with electrophysiologic measures documenting a link between morphologic and elctrophysiologic endpoints. Softening of unlasered TM in ExGl eyes compared to untreated controls was observed. The degree of TM softening was consistent, regardless of pre-mortem clinical findings including severity of IOP elevation, retinal nerve fiber layer thinning, or electrodiagnostic findings. Importantly, this softening is contrary to TM stiffening reported in glaucomatous human eyes. Furthermore, microscopic analysis of unlasered TM from eyes with ExGl demonstrated TM thinning with collapse of Schlemm's canal; and proteomic analysis confirmed downregulation of metabolic and structural proteins. These data demonstrate unexpected and compensatory changes involving the TM in the NHP model of ExGl. The data suggest that compensatory mechanisms exist in normal animals and respond to elevated IOP through softening of the meshwork to increase outflow

Validation of Immersed Boundary Simulations of Heart Valve Hemodynamics against In Vitro 4D Flow MRI Data

The immersed boundary (IB) method is a mathematical framework for fluid-structure interaction problems (FSI) that was originally developed to simulate flows around heart valves. Validation of FSI simulations around heart valves against experimental data is challenging, however, due to the difficulty of performing robust and effective simulations, the complications of modeling a specific physical experiment, and the need to acquire experimental data that is directly comparable to simulation data. In this work, we performed physical experiments of flow through a pulmonary valve in an in vitro pulse duplicator, and measured the corresponding velocity field using 4D flow MRI (4-dimensional flow magnetic resonance imaging). We constructed a computer model of this pulmonary artery setup, including modeling valve geometry and material properties via a technique called design-based elasticity, and simulated flow through it with the IB method. The simulated flow fields showed excellent qualitative agreement with experiments, excellent agreement on integral metrics, and reasonable relative error in the entire flow domain and on slices of interest. These results validate our design-based valve model construction, the IB solvers used and the immersed boundary method for flows around heart valves

Progress in achieving quantitative classification of psychopathology

Shortcomings of approaches to classifying psychopathology based on expert consensus have given rise to contemporary efforts to classify psychopathology quantitatively. In this paper, we review progress in achieving a quantitative and empirical classification of psychopathology. A substantial empirical literature indicates that psychopathology is generally more dimensional than categorical. When the discreteness versus continuity of psychopathology is treated as a research question, as opposed to being decided as a matter of tradition, the evidence clearly supports the hypothesis of continuity. In addition, a related body of literature shows how psychopathology dimensions can be arranged in a hierarchy, ranging from very broad "spectrum level" dimensions, to specific and narrow clusters of symptoms. In this way, a quantitative approach solves the "problem of comorbidity" by explicitly modeling patterns of co-occurrence among signs and symptoms within a detailed and variegated hierarchy of dimensional concepts with direct clinical utility. Indeed, extensive evidence pertaining to the dimensional and hierarchical structure of psychopathology has led to the formation of the Hierarchical Taxonomy of Psychopathology (HiTOP) Consortium. This is a group of 70 investigators working together to study empirical classification of psychopathology. In this paper, we describe the aims and current foci of the HiTOP Consortium. These aims pertain to continued research on the empirical organization of psychopathology; the connection between personality and psychopathology; the utility of empirically based psychopathology constructs in both research and the clinic; and the development of novel and comprehensive models and corresponding assessment instruments for psychopathology constructs derived from an empirical approach

Integrated photonic building blocks for next-generation astronomical instrumentation I: the multimode waveguide

We report on the fabrication and characterization of composite multimode waveguide structures that consist of a stack of single-mode waveguides fabricated by ultrafast laser inscription. We explore 2 types of composite structures; those that consist of overlapping single-mode waveguides which offer the maximum effective index contrast and non overlapped structures which support multiple modes via strong evanescent coupling. We demonstrate that both types of waveguides have negligible propagation losses (to within experimental uncertainty) for light injected with focal ratios >8, which corresponds to the cutoff of the waveguides. We also show that right below cutoff, there is a narrow region where the injected focal ratio is preserved (to within experimental uncertainty) at the output. Finally, we outline the major application of these highly efficient waveguides; in a device that is used to reformat the light in the focal plane of a telescope to a slit, in order to feed a diffraction-limited spectrograph.Comment: 15 pages, 11 figures, accepted to Optics Expres